Prognostic Cut-Off Value of Ki67 Proliferation Index in Borderline Mucinous Ovarian Tumors

Objective
 Ovarian borderline tumors (OBTs) are an intermediate
 type of ovarian neoplasm. mucinous borderline
 (MBT) the second most common subtype
 OBT. Because their uncertain pathogenesis
 and biological behaviour they cannot be classified
 clearly into benign malign categories. There is a
 need to identify a parameter that provides more prog-
 nostic information about clinical course can be
 evaluated easily in routine practice. Ki67 routinely
 used immunohistochemical marker strongly associated
 with cellular proliferation, including tumor cells.
 We aimed this study evaluate prognostic
 significance determine prognostic cut-off value
 counting MBTs investigate its relationship
 clinicopathologic features, recurrence,
 long term survival status also provide more
 literature.
 Material Method
 A total 20 cases diagnosed mucinous
 were identified. Immunohistochemical
 studies performed on representative
 sample tumor. Positive signal was nuclear it
 by two pathologists.
 Results
 proliferating index (P.I) value median of
 15%(1-47%) mean 16% P.I. reached
 statistically at 20% with
 progression 30% 5-year OS.
 (p=0.021 p=0.032, respectively). Although the
 tended increase age, there no
 statistical association between Kİ67 other clinicopathological
 parameters size, laterality,
 capsule integrity, intraepithelial carcinoma and
 focal atypia.
 Conclusion
 In our study, recurrence frequent when Ki67
 greater than 20%, lower
 30%, suggesting that
 associated aggressive
 death. Therefore, we predicted Ki 67 would useful determining frequency follow-up patients predicting prognosis.
 However, think result should supported
 larger series.